Characteristics of microRNAs in Skeletal Muscle of Intrauterine Growth-Restricted Pigs

microRNAs are a class of small RNAs that have been extensively studied, which involved in many biological processes and disease occurrence. The incidence intrauterine growth restriction is higher mammals, especially multiparous mammals. In this study, we found the weight longissimus dorsi growth-restricted pigs was significantly lower than normal pigs. Then, pig were used to characterize miRNA expression profiles by RNA sequencing. A total 333 miRNAs identified, 26 differentially expressed. Functional enrichment analysis showed these expressed regulate their target genes (such as PIK3R1, CCND2, AKT3, MAP3K7), play an important role proliferation differentiation skeletal muscle through signaling pathways such PI3K-Akt, MAPK, FoxO pathways. Furthermore, miRNA-451 upregulated IUGR muscle. Overexpression miR-451 C2C12 cells promoted Mb, Myod, Myog, Myh1, Myh7, suggesting may be regulation myoblastic cells. Our results reveal regulating myogenic with restriction.